San Francisco 49ers (5-4) vs. Arizona Cardinals (4-6)

The Spread: 49ers (-10)

I have absolutely no idea again. Colt McCoy gets the start at QB for the Cardinals which has inflated this line to 10 points. McCoy was able to lead them to victory last week against the Rams, but will he be able to keep it up versus a very good San Francisco defense? Deandre Hopkins is in line to play as we speak, but the Cardinals will be without Zach Ertz and Hollywood Brown. I think the Niners win this game no problem, but the line is scaring me a bit. It feels like the 49ers don’t blow teams out, but four of their five wins have been by more than 10 points. I’m having trouble picking against San Francisco here. I just think that we’ve already seen the Colt McCoy game this year and I’m not sure he’s capable of doing it again against a good team. I don’t love it, but I’m riding with the 49ers here.

The Play: 49ers -10

Total (43)

I’m just going to lay it all out for you here. I need Deebo and McCaffrey to go off for my fantasy team tonight so I’m picking the over strictly based off that. It’s a low number so I’m hoping if we can get a couple touchdowns on the board early we can get to this total. The Niners defense should be able to shut down the Cardinals, but if they can get into the upper teens points wise then for San Francisco to cover the over will have to hit. I just think this is slightly too low of a number for these teams even with McCoy in at QB.

The Play: Over 43

Final Prediction

49ers 30 Cardinals 17